Long-term therapy with bisphosphonates

Women who take bisphosphonates for 10-13 years have higher fracture rates, compared with women who take the medication for 2 years.

Recently, a team of researchers examined whether older women taking bisphosphonates for 10-13 years had fewer bone fractures than older women with similar fracture risks who took these medicines only briefly. Their study was published in the Journal of the American Geriatrics Society.The research team examined data from the Women's Health Initiative study, a large study that began in 1993 to develop ways to reduce heart disease, cancer, and fractures in women after menopause. The researchers looked at information from 5,120 women within the study. These women were bisphosphonate users with a high risk for bone fractures.

More than 95% of participants in the study were over age 70, with an average age of about 80. The length of time the women had taken bisphosphonates when the study started was as follows:

 

  • 13% for 2 years
  • 34% for 3-5 years
  • 20% for 6-9 years
  • 33% for 10-13 years
     

The researchers followed the women in the study for nearly 4 years. They discovered that women who took bisphosphonates for 10-13 years had higher fracture rates, compared with women who took the medication for 2 years. Taking bisphosphonates for 3-9 years was not linked to a higher fracture risk.

"Our study and several others have found higher risk of fractures among very long-term bisphosphonate users, compared with short-term users. However, the ideal length of bisphosphonate use has not yet been studied in randomized clinical trials, which are considered the gold standard of research studies. Therefore, long-term bisphosphonate users should see their healthcare providers regularly to decide how long to continue bisphosphonate therapy in their individual cases," stated Rebecca L. Drieling, MPH, an author of the study.